The film's female protagonist has blue eyes. The genetic mutation that gives rise to blue eyes emerged between 6,000 and 8,000 years ago, which lies outside the period depicted in the film.
Chilli peppers and maize are native to the Americas. They had not been cultivated in the "Old World" until after 1500.
The sequence featuring the ships depicts confinement cages crafted from iron, yet the Iron Age did not begin until around 1200 BC — roughly 8,800 years after 10,000 BC.
During the assault by terror birds, the scene depicts men mounted on horses. The earliest evidence for the domestication of the horse dates to 3,500 BC — roughly 6,500 years later than the period in which the film is set.
Advanced metalworking is depicted throughout the film — from jewellery to swords — technologies that did not exist in 10,000 BC; metal swords did not appear until about 3,000 BC, roughly 7,000 years later.
(at roughly the 50-minute mark) The leader of the African tribe tells D'Leh how his family were taken from him. When he calls out to a member of his tribe, a silver filling is clearly visible in his mouth.
The earliest Egyptian pyramid was built around 2630 BC. The film does not portray the Giza pyramids as complete, perhaps to accommodate both those who regard the Giza structures as relatively recent and those who believe they are considerably older.